Life Sciences

Dynamic Light Scattering (DLS) Particle Size Analysis

Next-generation multi-angle DLS turnkey design with built-in consistency checks, raw photon access, and intelligent spike filtering for fast, reliable particle sizing.

Figure 1. The image consists of two main parts: the top half is a schematic of a Dynamic Light Scattering (DLS) setup, and the bottom half shows the DLS analysis and comparison between large and small particles based on the measured data. Top: A laser source emits a monochromatic light that travels horizontally and enters a transparent sample container (a cuvette). Inside this cuvette, several blue particles are shown in random “Brownian” motion. A Single Photon Detector “SPD” is situated at an angle θ from the laser propagation to collect the scattering data from the sample. The correlator acquires and calculates the correlation of the timing data from the detectors in real time. A cable connects the correlator to a computer “PC”, where data analysis is performed. Bottom: Visualization of the different behavior of small and large particles in solution, represented as blue circles (dark and light blue, respectively) and with their hydrodynamic radius (Rs and RL, respectively). Three different analysis plots are shown underneath, from left to right: Left: Intensity vs. Time (s): Two jagged lines represent the fluctuations in light intensity over time.The large particle has slower and smoother fluctuations in light blue color. The small particle shows faster fluctuations in dark blue color. Middle: Autocorrelation Function (ACF) vs. log 𝜏 (s): This plot shows two autocorrelation curves that represent the diffusion behavior of particles suspended in the examined solution. The large particle's curve decays more slowly. The small particle's curve decays faster, reflecting quicker diffusion. Right: Intensity vs. Size (nm): A graph with two sharp Gaussian curves. The left peak is labeled Rs for the small particle. The right peak is labeled RL for the large particle, indicating a size distribution derived from the correlation data.

Single-Photon Counting Raman Spectroscopy

The single-photon counting Raman spectroscopy combines the principles of Raman spectroscopy with single-photon counting techniques, enabling the detection of weak Raman signals even at low analyte concentrations

Fluorescence Lifetime Imaging (FLIM)

Discover fluorescence lifetime imaging (FLIM), a powerful imaging technique for mapping fluorescence lifetimes with picosecond precision. Learn how Swabian Instruments' Time Taggers enable high-resolution FLIM measurements using advanced timing electronics, supporting detectors like PMTs, SPADs, and SNSPDs for cutting-edge research applications

Single Photon Microscopy

Did you ever wish you could save time by having all signals from your setup captured by one single device and made available to you by a versatile and intuitive software engine?

Life science encompasses a broad spectrum of scientific research evaluating the complexities of biological systems. This field includes the study of living organisms (structure and function), their life processes (origin, growth, evolution, distribution), and their relationships to each other within an ecosystem and with their environments. Breakthroughs in life sciences are required to advance healthcare, disease management, and our understanding of the fundamentals of life itself. By unraveling the mysteries of biological systems, life sciences research paves the way for innovative medical therapies, vaccines, and diagnostics, contributing significantly to enhancing life quality and extending life expectancy.

Swabian Instruments’ Time Taggers and time-correlated single photon counting (TCSPC) implementations are pivotal in life sciences as tools for studying cellular processes and molecular interactions with unmatched temporal precision via high-resolution fluorescence lifetime imaging and fluorescence correlation spectroscopy.